>>14387592>Most drug addictions and tolerance to drugs is usually created by your body naturally making less neurotransmitters to compensate for the consumption of neurotransmitter analogs you are taking.Not true. It's usually receptor internalization by phosphorylase that does the job. When many receptors are internalized, the molar concentration in the synapse has to be much higher to compensate for the lack of binding sites, as most of the ligands will end up drifting away unbound.
> Are there any drugs that stimulate you to continue making normal levels of the neurotransmitters in the presence of drugs?Generally, tolerance (in the form of internalization and the less common non-production of neurotransmitters) is an action mediated by glutaminergic pathways; the more glutaminergic a specific receptor subtype (mu-opioid in the basal ganglia, for example), the faster and longer lasting tolerance is experienced. For a bit of an anecdote: I used to bang a bunch of heroin and oxycodone. I once had a two year gap of not using at all, and when I went back, my tolerance was still pretty close to where I left off years prior. On the contrary, a circuit less involved in learned behavior (operant conditioning) will exhibit much less of this tolerance effect, but will still happen.
The only feasible way of preventing tolerance in a chronic user is to consistently dose with an NDMA antagonist, preferably one with a longer half-life than the main drug. However, this only slows the development of tolerance at the time a regimen is started. It won't reverse an already existing tolerance, but will slow the progression of one.
Also, your graph sucks.
