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If you want to free yourself from suffering, follow the Noble Eightfold Path. But these are just guidelines. Karma is real, it means that every cause has an effect. All causes are conditional.
There is no-self. Your Body isn't you. Your Mind isn't you.
Rebirth is real. When you die, your body dies, what carries over are 'sankhara' or mental volitions, because these things are the cause of Mind. Through meditation practice, you will gain insight into the true nature of reality. All material things are impermanent.
By realizing this, you will cease attachment and clinging to material objects, which perpetuate the cycle of suffering. This will allow your mind to become equanimous with the present moment. When your mind is as still as it can be, nibbana remains.