>>13431654The authors studied the protein sequence from the spike (S) protein of SARS-CoV-2. The spike (S) protein is the one which binds to ACE2, a receptor protein on human cells, so that the virus can enter. There is a specific part of the S protein which binds to ACE2, it's called the Receptor Binding Domain.
The authors analysed the protein sequences from the S proteins of multiple coronaviruses and found that they contain some Prion-like Domains (PrD). The PrDs are special because they can move around a lot. Authors found that while all coronaviruses have PrDs in their S protein, only SARS-CoV-2 has PrDs in its RBD.
Furthermore, they analysed the sequence from ACE2 and found that it also had PrDs.
Altogether, they feel like the PrDs in the RBD of the S protein are very good at making sure that there's a nice link between S protein and ACE2.
It was interesting read but I don't feel like there's enough data to convince me that PrDs are beneficial to such an extent.
Also this is a preprint :((( maybe you should wait for the peer-review before posting?