The purpose here is to present clear, rational, and valid reasons for vaccine hesitancy among those unvaccinated so that we might achieve some consensus regarding the risk benefit of our current mass vaccination campaign. Claims are sourced. We will look at the larger picture then focus on the wild-type SARS-CoV-2 spike glycoprotein (WT, SP), the target for all our current generation of mRNA vaccines and it's relationship to the Angiotensin-Converting Enzyme 2, (ACE2).
1. Mass vaccination during a pandemic leads to more virulent strains, not less.
Corona viruses have a fast mutation rate, especially, the C.1.2 variant from South Africa (?41.8 mutations per year, double WT)[1]. When a virus is exposed to a wide range of immune respones, (unvaxed-vaxmax), the virus will be selected towards higher virulence and infectivity [2,3] This is primarily because the immunity conferred by the SP does not prevent infection and transmission as evidenced by the dropping rate of vaccine effectiveness around the globe against variants [3], we also know Corona viruses spread among different species. These two main factors ensure the viral load in the community remains high despite vaccinations. Variants of interest include: Delta, C.1.2, AY3, and Mu.
1. Mass vaccination during a pandemic leads to more virulent strains, not less.
Corona viruses have a fast mutation rate, especially, the C.1.2 variant from South Africa (?41.8 mutations per year, double WT)[1]. When a virus is exposed to a wide range of immune respones, (unvaxed-vaxmax), the virus will be selected towards higher virulence and infectivity [2,3] This is primarily because the immunity conferred by the SP does not prevent infection and transmission as evidenced by the dropping rate of vaccine effectiveness around the globe against variants [3], we also know Corona viruses spread among different species. These two main factors ensure the viral load in the community remains high despite vaccinations. Variants of interest include: Delta, C.1.2, AY3, and Mu.
