>>114103080A lot of batman's gallery can be killed with normal guns, let alone huntress weapons. The others was still vulnerable to elemental stuff which dust covers so yeah, most of Batman's isn't really a threat in a straight fight and they have enough raw power to brute force through the trickier ones like Riddler and shit.
Spidey's is far more variable in power level. Shit like Vulture, the goblins and shocker would lose but stuff like the symbiotes? Those would be a lot more questionable, especially what with Carnage being basically immortal... which also brings up the variable power levels even the individuals have through out the series; one version of a villain would be cake while another version of the same villain is power made flesh.
Overall in a general sense though, they could take probably MOST of spideys and nearly all Batman's. Aura alone would give them a bug advantage and huntsmen are already base level super human. Even in-training huntsmen pull some pretty crazy shit in the show. Plus they have limited toon force in some episodes being a goofy sudo-anime early on.