I know that Amazing Spider-man #837 has to be on there because it was the first comic with full immersive VR interface.

Also probably Flatzoners #3 (first published May of 2031) that included a printcode which let you homeprint a version of the Flatstriker's gun that actually worked and 2 kids died which led to all that annoying 3D printer legislation.

What are your picks /co/?