>>98031356My wife is my best friend, so yes.
Platonically though, I definitely think it's possible, but probably not common. If they're both straight and close enough to be best friends, it's only natural that they would become attracted to each other sooner or later, unless one is super ugly or something. Sometimes though, things just don't click romantically for whatever reason, even if you do get along really well as friends, so I'm sure there are some straight, opposite-sex platonic best friends out there.