>>93124894One of the more famous Punisher storylines dealt with Ma Gnucci, mother of the heads of the Gnucci crime family. Frank, being Frank, killed the sons, and fed Ma to a polar bear when she came for revenge. She ended up quadriplegic for a brief time before Frank came back to finish the job.
The clones were actually surgically altered quadriplegics, who had been recruited by one of Frank's enemies to try and drive him crazy by claiming she'd risen from hell, immortal, to lead NYC's crime families to kill Frank Castle.