Then the franchise fails because as it turns out boys do not want merchandise of female heroine type shit. Look at how much Rey from Star Wars merchandise sells....oh wait it doesn't. Even relatively successful action girl shows like Kimpossible don't inspire boys to want to buy merchandise.
Seriously now if the franchise was called Gwen 10? It would have failed at the first series. Forget reboots it simply never would have lasted after the first series which probably also would have less seasons in total. Don't expect female lead anything to impress boys, look at the recent Ducktales it's basically The Webby Adventure Show. No one actually liked the whole thing or Webby. And if I'm honest Gwen is a very annoying character that only child molesters found entertaining.
So game over, Gwen 10 would have failed. DC had planned a Batgirl cartoon series at one point and teased at it with the final episode of Batman Brave and Bold, never got off the ground though and if I had to guess it's because they realized it would not sell any merchandise.