Hello Nurse.

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>In a recent interview with The A.V. Club, Animaniacs showrunner Gabe Swarr and executive producer Wellesley Wild tried answering that question by commenting on their approach for bringing back the wacky Warner trio, the difficulties of planning two years ahead since production began in 2018 and some of the cultural differences that surfaced in that 20 year gap since the show ended.
>One of the victims of this cultural paradigm shift was nurse Heloise Nerz (yes, she has a name), Yakko and Wakko’s crush and the blonde target for the brothers signature “Hellooo nurse!” catchphrase. As Swarr puts it, “immediately hello nurse was goodbye nurse”, noting that running gags like these simply wouldn’t work in 2020.
>The interview goes a little further explaining how the characters and jokes were updated in several ways, including Dot being re-imagined as more of a feminine force that now outsmarts her brothers even more than she did in the past. It’s worth noting that while both producers seem very happy with how the Animaniacs look in 2020, the difficult animation process meant that pre-planned episodes featuring events like the 2020 Tokyo Olympics are still featured despite the sporting event being postponed.