>>114641463That isn't so bad, as if you didn't know anything about metal gear, she's just acting like a macho action hero. An overt reference is fine so long as the joke it's supposed to be making is still conveyed. Though it may have the effect of annoying or distracting your audience, so that's something to consider (like the overused wilhelm scream).
Another big no no is if the reference outright takes the place of a joke, which happens in ops
>>114641330 image.
That coulda been a sexy lady, a sexy dude, an overt ugly anime looking character, all of those would have been immediately more amusing than "here's snake". That isn't even a joke, it just replaced one. Bad. Shitty.