>>106354732I mean, it's already pretty tryhard. At least in the comics and toons.
I'm imagining an episode of the cartoon where it's 63 for no reason from the start. They'd probably vaguely refer to something feeling off, but everything else throughout the episode would be carry on as usual and that would be the joke. Nothing would really change. Maybe a crook would try pointing it out at some point but would get interrupted by Sam and/or Max with their trademark needless violence.
Dwelling on the fact that they're women throughout the episode would defeat the purpose and it wouldn't be funny. I'm not sure what you're imagining.