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Below average to downright awful writing by 13 writers. One writer went out of his way to create an offensive portrayal of a fan of the original, even adding extra clothes to increase his on-screen weight and stopped shaving to have a neckbeard.
Poor acting. In a perfect example, in what I hope is the final episode of the series ever, the kids are falling into a "cyber" (everything is a "cyber" this and "cyber" that... even the fucking catapult is a "cyber catapult") black hole and it's some of the worst acting I've ever seen.
CG sequences aren't very good. But when you have an idiot president who forces the studio to use the Unreal Engine, and nobody has ever used it before, the results are going to be bad.
The only true callback to the original and only episode to feature Mainframe or Bob, Dot, and Enzo is pretty shitty. Dot's a coward, Bob rambles his intro speech to random strangers, Enzo doesn't do anything aside from saying his catchphrases and Frisket whimpers at the mention of Megabyte's name (remember Frisket was a tough dog).
TL;DR - Shit writing, shit acting, shit CG, shit live-action, shits on the original and it's fanbase.