Oh definitely, although I guess the argument here is that Marge by default sacrifices more since she gave up her future to raise one kid after the other (putting aside the question of contraceptives since from a meta perspective they came up with the cast of the show before rationalizing how they got to that point.)
Yeah, as a homemaker she doesn't have to go work for the person who forced Homer's mom into a life of exile, and exposes his workers to literal toxic materials in an unstable power plant but Homer didn't exactly have talents and passions like she did for the arts that were squashed, squandered and taken away from her as she went on to raise two kids, each of whom are for different reasons not appreciated by society.
While this is more because The Status Quo is God, any time Marge has tried to branch out--by becoming a police officer, or start her own business, help an ex-con try to get back on his feetetc.-- the show makes it a point that she fails or quits the endeavor by the end of the episode.
Objectively we know why this happens, but it can be disheartening if you legitimately root for Marge. Apart from her family/marriage remaining stable her victories are fewer than Homer's