>>5909246i work on high res images too, i don't need color mixing really until detail passes with smaller brushes. you asked for block in.
stroke > gap.
the fastest color mixing i've found (and closer feeling to ps) is running color, fixed amount 0.0. then 100-100, and play with color stretch to your desire. i have amount and density set to pen pressure with the pressure curves looking like this but the bend as far to the bottom right as possible.