- The Scarlet Witch creates the “Multiverse of Madness” after falling under the influence of Nightmare. Doctor Strange must rescue her to prevent the collapse of reality.
- Strange assembles a team of sorcerers to help him navigate the Multiverse of Madness, consisted of Wong, Mordo, Clea and Drumm. Strange and Mordo clash on whether Wanda can be saved or must be executed. Strange and Clea develop a bond. Wong and Drumm have an unlikely friendship.
- Benedict Cumberbatch, Elizabeth Olsen, Benedict Wong and Chiwetel Ejiofor are (obviously) returning. Rebecca Ferguson and Aldis Hodge are in talks for Clea and Drumm. Tilda Swinton will make an appearance as the Ancient One.
- Several high-profile male and female actors are being discussed for Nightmare, including Eva Green, Emily Blunt, Claire Foy, Vanessa Kirby, Natalie Dormer, Ewan McGregor, James McAvoy, Cillian Murphy, Dan Stevens and Jared Leto.
- Strange assembles a team of sorcerers to help him navigate the Multiverse of Madness, consisted of Wong, Mordo, Clea and Drumm. Strange and Mordo clash on whether Wanda can be saved or must be executed. Strange and Clea develop a bond. Wong and Drumm have an unlikely friendship.
- Benedict Cumberbatch, Elizabeth Olsen, Benedict Wong and Chiwetel Ejiofor are (obviously) returning. Rebecca Ferguson and Aldis Hodge are in talks for Clea and Drumm. Tilda Swinton will make an appearance as the Ancient One.
- Several high-profile male and female actors are being discussed for Nightmare, including Eva Green, Emily Blunt, Claire Foy, Vanessa Kirby, Natalie Dormer, Ewan McGregor, James McAvoy, Cillian Murphy, Dan Stevens and Jared Leto.