That will never happen. The first and most important thing Antonucci wanted when pitching Ed, Edd n Eddy is to keep the IP, which he was permitted.
The difference with Powerpuff Girls is that McCracken sold the IP to CN - they are the sole owners of the characters.
CN legally can't make a reboot of Ed,. Edd n Eddy without Antonucci's permission - and when he was asked about the prospect of a reboot, he clearly discarded it.
And really, do you want a Ed, Edd n Eddy reboot? The show was great and had a fantastic and probably one of the best series finales in televised western animation. And it was clear to see the A.K.A. Cartoon crew ran out of steam around seasons 4-6.