Age of The Joker
The is able to form a team of the smartest people on the planet for the soul goal of turning every person on the planet as insane as The Joker himself. This works on every human, but not the aliens. So he goes though space make everyone as crazy as him in the whole universe. He fails at this for the most part, but turns Darkseid into Joker-Darkseid. Joker-Darkseid kills The Joker, but continues goal and succeeds.
Years later, the universe is insane, both metaphorically and literally. But there is a group of heroes fighting back against this madness, calling themselves 'The Sane-Men'.