>>11055084accuracy referring to "how specific are the edits that are made". in a perfect system, CRISPR would only edit the exact location you want it to, and insert/delete the exact sequence you want it to. This relies on more than just the CRISPR/Cas9 system, especially for edits that insert more DNA rather than just disrupt a gene (a knock-in versus knock-out). There is a lot of interest in knock-ins, but they are inherently more difficult to accomplish as it requires more dumb luck to work.
solving it is happening, people are designing better Cas9 proteins, better ways to design those templates for targeting, and really clever ways to manipulate how the cell repairs the cut CRISPR makes, to make it more specific to what you want it to be.
Timeframe? now if you have a decent amount of time and money. It works, it just takes some time to get right, like most of this stuff. The idea now is to make that "time to get it right" down to nothing, and probably come up with programs to just spit out templates for common site edits
