>>107625595>>107625639The only villains confirmed fictional are Megavolt, Quackerjack, Bushroot, and Liquidator. There's an easy way around that.
First, the now criminally insane Jim Starling/Negaduck will steal various experimental technologies, some of which have already been seen on the show (von Drake's rapid plant growth liquid from the Doomsday Vault episode, Gandra Dee's electric handprint from her episode, etc.)
He gives this tech to some small time criminals (perhaps a group of Beagle Boys who've been cut off from the rest of the family for some reason), and they become his gang, the Fearsome Five.