They can, granted that not having romantic feeling for each other would further the story they're writing.
But this show isn't heading this way that's for sure. It's too late to make a 180 turn now.
This show isn't the "one" that's guaranteed to satisfy those who are sick of main characters getting together.
Though I'd find it amusing for a show to promise "The Misadventures of the Boy and Girl who are best friends and obviously have romantic feeling for each others, as they try their best to deny their feelings and hook up with other people, and complain they can't keep a relationship because it isn't fulfilling to them at all".