It's always questions about how LSD is made, new route ideas, how it works in the brain, LSA, or new LSA experiments. Still studying O-Chem. I think it's all about how can we make LSD feasible for those with decent O-Chem knowledge. Btw the essential amino acid LSA theory:
https://boards.fireden.net/sci/thread/11357462/#11359746has yet to be disproved. I think that Phenylalanine is more important than Luecine to the theory. Phenylalanine competes with Luecine for the same receptors (both are very similar), is found in breast milk, and has anti-depressant effects. Why would phenylalanine have anti-depressant effects? It must correlate to increased serotonin (5-HT2A receptors) signaling.
"The extracellular loop 2 leucine 209 residue of the 5-HT2B receptor forms a 'lid' over LSD that appears to trap it in the receptor, and this was implicated in the potency and functional selectivity of LSD and its very slow dissociation rate from the 5-HT2 receptors"
-LSD wikipedia page, taken from the published Cell paper on how LSD works
I don't comprehend what the EL2 Luecine 209 residue does but it seems to relate to Luecine receptors in the heptahecial TMs near the 5-HT2A receptor. Supposedly there is a non-polar attraction between something on this EL2 Luecine 209 residue (Luecine molecule, end of the isobutyl tail?) and the diethyl groups. I wonder since Phe has an aromatic ring (bigger, trap molecules easier?) if that could effect serotonin, LSA, or 4-HO-DMT for prolonged antagonism. Obviously this will never be as good as LSD's binding. If Luecine also does this, it would be trapping less molecules entering the receptor because of size. Maybe that's why women like Pumpkin Spice so much (rich in Luecine, the seeds at least). If anyone feels like sharing a practical LSD synth from LSA that would be awesome.
