>>11358890>generally structure has little to do with effectI thought substitution determines pharmacology because it changes the absorption rate [how fast does it cross the blood barrier (BB) and blood brain barrier (BBB)], binding affinity, efficacy, weight, and size of the molecule.
>1) how well they stick to which receptorsLSD has a diethyl moiety that helps it stick to receptors like 5-HT2A because of non-polar attraction to other adjacent receptors/molecules. The contracting shape the receptors make further helps to encapsulate LSD in place on the receptor. LSA doesn't have this moiety, so its binding affinity is much lower.
>2) how fast they can be washed out
This is correlated to binding affinity, but also how the body might choose to break molecules down if necessary to flush them out.
>3) how fast they catalyze neurotransmitters between junctions?
>>11359383I don't understand how consuming beta-hydroxybutyrate (BHB) in this concoction could change the structure of the molecule in vivo unless gastric acid/enzymes did something. The ethanol and ether are for increasing absorption into the blood stream, while BHB is "supposedly" capable of being a shuttle bus for certain drugs to cross the BBB.
"Phenylalanine will also interfere with hydrophobic amino acid transport across the BBB. It competes for the same active transport system as does leucine..."
https://www.sciencedirect.com/topics/neuroscience/phenylalanineOriginally, the idea was for LSA to become LSH by gastric acid, ethanol, and acetaldehyde and to have it actually reach the brain before being broken down and destroyed. Supposedly, LSH on its own cannot cross the BBB. After reading the Cell paper on how LSD works in the brain and watching lectures on psychedelic science by David E. Nichols to understand how it binds, it seems to relate to amino acids and their receptors adjacent to the 5-HT2A (as well as other neurotransmitter receptor targets for the drug). I call it LSHB.
