>>13335248Desloratadine, the main metabolite of the Claritin you posted, has some very interesting properties.
I recently had a strange reaction to Claritin (I never take it), but the first day I took it (in combo with L-Theanine) and smoked a lot of tobacco as well, I ended up with a profound relief of depression. I posted it about it on plebbit, and someone mentioned an uncited response that it may have DRI properties, but doesn't seem to be much to support that notion yet.
One interesting property of Desloratadine is that in inhibits a variety of enzymes. It lightly inhibits a few, and strongly inhibits one particular enzyme...UGT2B10. UGT2B10 is the enzyme primarily responsible in gluconating nicotine, allowing it to become water soluble and then excreted via urine. My gut feeling was that I was experiencing some kind of intensely enhanced response to nicotine, accumulating large amounts of it in my blood. But it's just a guess. I went down a rabbit hole and found nothing concrete beyond its TCA structure to explain the mood boosting effects. They were acute, and lasted all day. Have yet to be able to replicate those conditions again though...it's frustrating, because I would give anything to feel like that again, and it's become a project of mine to sniff out possible causes for said effects.
>https://en.wikipedia.org/wiki/Desloratadine>https://en.wikipedia.org/wiki/UGT2B10Dig around, check that list of effected enzymes. I'm only mentioning one of a few.
I truly think we will see Claritin repurposed in some way, eventually. Seems promising, but also elusive in it's action.
Given the acuteness of my anecdotal effects, I have this gut feeling that it may be hiding a rapid relief mechanism when used under certain conditions/with the proper catalyst. At least I hope, as opposed to just nicotine toxicity lmao. I would literally donate real money to fund further studies into Desloratadine and it's metabolites.
