Is there any theoretical mechanism behind the hedonic treadmill and neuroadaptation?
Would it theoretically be possible to eliminate the tolerance reaction to make every orgasm, drug, love, taste of your favourite food; everything feel as intense as the first time, every single time? Be it through psychosurgery, CRISPR or drug therapy? Is there any research done in this area through animal knockout studies?

This seems to be the end goal of all human research; never ending never lessening pleasure from birth to death