Calculus/Physics Question

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I took calculus when I was majoring in bio but I was 18 when I took it and it was the nerfed version of it.
Consider the physics equation for voltage, current, and resistance V=IR
Every function has a coefficient, in this case, 1.
In the equation for gravity there is a coefficient "G" which is non-1
In calculus for function y=x,
the integral is y=(x^2/2)+C
derivative is 1

My question is whether or not my assumption about every scientific experiment that historically led to derivations of constants was based on applying calculus with said assumption? Thanks