>>13173485Well a perforated gut would allow significant translocation of bacteria and all their shitty byproducts directly into the bloodstream. Increased permeability of the small intestine would allow proteins to be absorbed before they're fully broken down, and that could lead to an immune response because proteins are seen as foreign invaders. Immune response = food allergies, arthritis, inflammation, etc. Also, it was found that alcohol itself isn't directly harmful to the liver. What causes liver disease in alcoholics is the translocation of bacteria. Coffee, which has been found to be highly protective of the liver, tightens gut junctures. So there's plausible mechanisms where increased permeability, which can result from alcohol, certain proteins (gluten, casein), and intestinal overgrowth, could lead to other systemic issues.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345535/ 
