Can Wellbutrin, Guanfacine, or Strattera interfere with the effects of MDMA? I took 100mg of MDMA on an empty stomach and it was so fucking boring. I even tested it with 5 reagents to make sure it was real. No intense emotions, euphoria, or increased empathy whatsoever. I was just bored and tired and started coming down 2 hours in. I was a bit stimulated and while it wasn't a good kind of stimulation, it wasn't bad either. Just meh. The last time I took it was over 2 years ago when I wasn't on my meds and it had similar effects (didn't test it that time though), but I do remember it being more enjoyable. Still didn't feel any different emotionally though.