>>12963809there's a few mechanisms that prob would work
mainly, if you have a bunch of cells producing spike proteins outside the area of the body where immune cells are trained (lymph nodes, thymus whatevs), then your immune cells will recognize them as foreign, even though its your own cells making them.
in a disgusting simplification immune cells are selected for in two ways
1) when first made, they are selected to not kill important shit that you are made of. this is done via "examples" being given to them during their initial creation, via AIRE and some other proteins. This is why your immune cells don't obliterate your entire body (unless you've got some fucked autoimmune disease)
2) later in life, when immune cells spot something that's weird as fuck, they get all excited and are assisted to duplicate a whole lot.
the basic premise of an mRNA vaccine is to turn some cells in your body into sacrificial teachers of a sort, with the benefit that the "example" you're being trained to attack is very, very close to the "ideal" indicator of the virus. (the spike, in this case).
unfortunately, this can lead to some poor outcomes if injected in the wrong spot, and could cause your immune system to develop some poor habits.
so says a couple of semesters of immunology, a number of /sci/ posts, and a decent amount of talking out my ass.
