>>12929406I know dietary interventions are common alternatives since to this day, there is no exhaustive treatments.
We know autistic brains seem to exhibit higher inflammatory markers in their white matter due to genetic factors that decrease antioxidant response in brains, which are the most free radical producing organs.
>We demonstrate an active neuroinflammatory process in the cerebral cortex, white matter, and notably in cerebellum of autistic patients.>https://pubmed.ncbi.nlm.nih.gov/15546155/Up to x200 times some inflammatory markers.
Sulforaphane, a potent anti-oxidant, seems to be effective in dealing with this.
In this study, for example, supplementing sulforaphane to autists showed substantial improvement in social interaction, abnormal behavior, and verbal communication.
>https://pubmed.ncbi.nlm.nih.gov/25313065/Sulforaphane is mostly found in cruciferous vegetables, like broccoli.
Another factor is a gut-brain connection too.
More chemicals like exorphins, opioid (morphine-like activity) peptides derived from food proteins, are let in that exacerbate autism symptoms.
Casomorphin peptides, that mostly come from the breakdown of beta-casein in dairy products, contribute one of the biggest sources of exorphins in our diet right alongside gluten.
This factor is where the diary-free gluten-free comes in.
Autists have higher intestinal permeability.
>https://pubmed.ncbi.nlm.nih.gov/20683204/Their blood-brain barrier is also thinner.
>https://pubmed.ncbi.nlm.nih.gov/27957319/ Autism severity correlates with casomorphin concentrations.
>https://pubmed.ncbi.nlm.nih.gov/24657283/There are plenty of studies to support dairy-free gluten-free diet. However, there is no conclusive double-blind study that found significant difference.
