>The population SD for the trait corresponds to an excess of roughly N^(1/2)vpositivevalleles (for simplicity we suppress dependence on minor allele frequency). A genius like von Neumann might be +6 SD, so would have roughly 6N^(1/2) more positive alleles than the average person (e.g.,?600 extra positive alleles if N = 10k). But there are roughly +N^(1/2) SDs in phenotype (?100 SDs in the case N ? 10k) to be had by an individual who has essentially all of the N positive alleles! As long as N^(1/2) >> 6, there is ample extant variation for selection to act on to produce a type superior to any that has existed before.
>Accurate prediction of height from genome has already been accomplished, identifying 10k positively associated loci (https://www.biorxiv.org/content/biorxiv/early/2017/09/18/190124.full.pdf). The genetic architecture of intelligence is similar to that of height (https://arxiv.org/pdf/1408.3421.pdf). It is only a matter of time before enough genotype-phenotype pairs are collected to perform a similar analysis on cognitive ability, and identify the estimated 10k SNPs that explain the variance in IQ. After these are identified, an optimized genotype could be discovered and implemented in human embryos via genetic engineering, although the technology here will also have to advance to be able to edit 10k loci reliably.
https://www.biorxiv.org/content/10.1101/574020v2
>Base editing with reduced DNA nicking allows for the simultaneous editing of >10,000 loci in human cells.
So. When are we going to start?
>Accurate prediction of height from genome has already been accomplished, identifying 10k positively associated loci (https://www.biorxiv.org/content/biorxiv/early/2017/09/18/190124.full.pdf). The genetic architecture of intelligence is similar to that of height (https://arxiv.org/pdf/1408.3421.pdf). It is only a matter of time before enough genotype-phenotype pairs are collected to perform a similar analysis on cognitive ability, and identify the estimated 10k SNPs that explain the variance in IQ. After these are identified, an optimized genotype could be discovered and implemented in human embryos via genetic engineering, although the technology here will also have to advance to be able to edit 10k loci reliably.
https://www.biorxiv.org/content/10.1101/574020v2
>Base editing with reduced DNA nicking allows for the simultaneous editing of >10,000 loci in human cells.
So. When are we going to start?
