>>12814677it's not. in pharmacology there is sometimes a problem between theory and practice because god hates us so much that he made the body extremely complicated. what in theory should just be "we inhibit,change, target, etc pathway X to get/get rid of Y" ends up sometimes working sometimes not, not having any effect or having another effect.
there is actually a lot of opposition to using SSRIs to treat any "sadness", if you go to a doctor and tell him that you always feel tired and not want to do anything he will most probably make you do a blood test to check iron, vitamins, etc or hormones if you are old or have related symptoms.