>>12713364 Thank you for your sophisticated response; it’s a rather accurate depiction of the mainstream opinion. I will still go at it a little bit.
>but that's true for the COVID mRNA vaccinesIt’s mostly true for all vaccines. If you really look at the literature, there is next to nothing showing anything. If you want we can discuss vaccine production. You can give me any study with methodology, which we can discuss. You will always see the issues. Mostly blatant conflicts of interest are obvious too.
>you don't generate neutralizing antibodies to Spike because Spike is a transmembrane protein and It happens according to mainstream opinion, but it’s rare. In the end my personal take on antibodies is they are probable misunderstood. Essentially they stick to almost anything, given the right conditions. IgX are mostly there to help leaking cells. They suspend and bind with the energy rich hydrosulfide groups.
>so the response is driven either by CD8+ T cell response to altered-self protein on MHCI or plasmacytoid dendritic cell MHCII presentation, which is far different from endocytotic extracellular pathogen recognition that you'd find in a classical inactivated-virus vaccine.Well pretty accurate recollection of the narrative. However the inactive virus itself gives next to no response at all. E.g. if it’s thermally inactivated. It’s always the other components in the plaque assay. And the Adjuvants. But we could get into that,
>Also, the concept that the virus is going to "mutate" into some wildly pathogenic strain and force us to continue making new vaccines is retarded because most people already have cross-reactive antibodies specific to the evolutionarily conserved transmembrane domain of spike called S2 that confer them some degree of protection, from having been exposed to seasonal coronaviruses as part of the common coldVery correct. Even according to the mainstream opinion, but it doesn’t count anymore.
