82KiB, 400x500, Deplin-Pamlab-11646-p-1.jpg View SameGoogleiqdbSauceNAO Anonymous Fri 12 Feb 13:19:43 2021 No.12697212 ViewReplyOriginalReport Quoted By: >>12697224 >>12698530 Is an MTHFR defect really a big deal? I only have 1 defect, but wondering if it's the reason antidepressants aren't helping me. Wellbutrin worked for me for a few months and now I'm wondering if I should ask for it again and maybe Deplin wirh it.