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Only the mercury isotope 196Hg, which occurs with a frequency of 0.15% in natural mercury, can be converted to gold by slow neutron capture, and following electron capture, decay into gold's only stable isotope, 197Au. When other mercury isotopes are irradiated with slow neutrons, they also undergo neutron capture, but either convert into each other or beta decay into the thallium isotopes 203Tl and 205Tl.
Using fast neutrons, the mercury isotope 198Hg, which composes 9.97% of natural mercury, can be converted by splitting off a neutron and becoming 197Hg, which then decays into stable gold. This reaction, however, possesses a smaller activation cross-section and is feasible only with unmoderated reactors.
It is also possible to eject several neutrons with very high energy into the other mercury isotopes in order to form 197Hg. However such high-energy neutrons can be produced only by particle accelerators.[clarification needed].
In 1980, Glenn Seaborg transmuted several thousand atoms of bismuth into gold at the Lawrence Berkeley Laboratory. His experimental technique was able to remove protons and neutrons from the bismuth atoms. Seaborg's technique was far too expensive to enable the routine manufacture of gold but his work is the closest yet to emulating the mythical Philosopher's Stone.[14][15]
