>>12678296Probably that’s part of the answer, we know these structures villi (like structures), exosomes/microvesicles. Just endocytosis and exocytosis. There is a hole field that studies apoptotic bodies. Oncosomes, exophers and exomeres etc. And we know they can carry everything from proteins, all kinds of RNA, DNA and lipids. It’s possible you can even make somebody sick with enough of that stuff. If somebody has massive amounts of interferon antagonist, damaged proteins of any kind or cytokines in these vesicles; I personally wouldn’t be sure, if it couldn’t in fact produce illness in somebody else, depending on amount and and way of introduction. The de novo alignment, however based on fishing with primers isn’t even that sophisticated. It just hits all kinds of sequences from genome and transcriptome, which are very present in the extra cellular fluid during „infections“ or better illness. Same goes for the proteins that can be found. If you „extract“ the probe brutally enough, meaning you damage cells, chances of the test always ending up positive approaches one. Because everything „viral“ is present in there. Since more than fifty percent of our genome is allegedly of „viral“ origin. Sometimes it’s hilarious and even the most „creative“ alignment programs can’t close the massive gaps. Than that’s just claimed to not be a single stranded genome. If as geneticist, system biologist, biochemist, molecular biologist, carefully want to counter this stuff, you can’t flat out say it (science is anything but free) and you need to go for a road along the line of, how do we know viruses aren’t transposons and retrotransposons that „escaped“ from our genome.
