Paul Stamets microdose stack

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Anyone experimented with Paul Stamets Neurogenesis stack?
Thinking of giving it a go, the only thing giving me pause is the niacin dosage.
100-200mg seems like a lot and the upper limit on niacin is generally 35mg in adults.
However adverse effects tend to manifest at 1000mg and up.
The dosage averages out to 71mg per day which is double the dose. Anyone have any insight as to whether this is safe? my intuition says yes.

Info on the stack
https://www.nootropedia.com/paul-stamets-epigenetic-neurogenesis-stack/

Info on the stack
https://www.nootropedia.com/paul-stamets-epigenetic-neurogenesis-stack/