>>12525707Following on from
>>12525827>how did they chose a placebo for a completely novel mRNA vaccine that requires the injection of transfection reagent? Typically with vaccines that contain adjuvants, you may use the adjuvants alone or some analogous adjuvant as an active placebo. However, RNA vaccines have intrinsic adjuvant effects (see Sahin, U., Muik, A., Derhovanessian, E. et al. 'COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses')
This has again been confirmed for the Pfizer BNT162b2 vaccine in the phase I/II trials (See Mulligan, M.J., Lyke, K.E., Kitchin, N. et al. 'Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults'). The RNA vaccines being given for Covid, don't have any adjuvants. In fact, aside from the RNA itself, the only ingredients the Pfizer vaccine has are some lipids, cholesterol, salt, and sugar (substances with no significant adjuvant properties) to aid in RNA delivery (
https://www.fda.gov/media/144245/download)
So since an active placebo wasn't suitable, saline is used
>Why did placebo group report nearly no symptoms of fever, localized swelling of muscle at site of injection compared to the nearly one third in the treatment group? See
>>12525418 and
>>12525394. Saline is just salt-water anon, that's why there were no notable immediate reactions. The study itself states: "This distribution largely reflects the inclusion of transient reactogenicity events", i.e expected events for a vaccine
>Why not say what the placebo was?In the exact words of the safety study itself: "With the use of an interactive Web-based system, participants in the trial were randomly assigned in a 1:1 ratio to receive 30 ?g of BNT162b2 (0.3 ml volume per dose) or saline placebo.". It is saline, this has been stated plainly
Anon, this information is publicly and freely accessible to anyone who can read. Why didn't you just invest the few minutes to find this out for yourself instead of asking on /sci/?
