Sup /sci/, I have determined the precise mechanism of action of topiramate!
It supplants PLP in glutamate decarboxylase, changing the reaction into a deamination. This causes hyperammonemia and headache relief.
If it does the same to serine hydroxymethyltransferase, it will cause glycine deficiency, thus collagen deficiency, thus topiramate hair loss.
Prove me wrong! Are hair loss and hyperammonemia explained elsewhere?
I'm going in the history books!