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generally, it's good to look at drugs and psychological health in the same way as diet and weight. if you have a single night of eating a bucket of KFC chicken and drinking a ton of soda, you're not going to get fat, but if you do that sort of thing semi-frequently, it'll be a problem. same deal with drugs -- you can do some pretty intense psychoactives as a one-off thing and generally be fine, but if you actually let yourself fall into addiction and frequent use, you're going to cause serious issues with your reward systems. even then, psylocybin mushrooms aren't generally seen as a high-risk substance. it's the ones like MDMA you have to tread carefully with.