Hybridizing animals

No.12343938 ViewReplyOriginalReport
What is the main obstacle that stops one animal from having offspring with another? Someone told me that it's genetic distance plus chromosome count, but then horses and donkeys are more distant genetically than humans and monkeys but mules exist and man-apes don't. So someone give me a QRD on this shit. BTW I'm willing to accept that man-apes do exist if there is evidence.