>The team next tested whether drugs that are known to eliminate senescent cells, called senolytics, could slow or reverse these effects. A cocktail of two senolytic drugs, dasatinib and quercetin, was given to young mice either at the same time as transplantation of senescent cells or 5 weeks afterward. When the researchers gave the cocktail over 4 months to mice who had aged naturally to the human equivalent of 75 to 90 years of age, they saw similar improvements in physical abilities compared with untreated mice. Mice who received the drugs also lived 36% longer on average and were no more frail near their delayed time of death than controls.
https://www.nih.gov/news-events/nih-research-matters/eliminating-senescent-cells-extends-healthy-life-mice
I have reason to believe this 36% increase in mice will translate into a ~30-40% increase in humans. Firstly, humans have proportionally more senescent cells than mice. Secondly, Since this drug is not a calorie restriction mimetic, it's positive effects will not diminish when given to a larger organism. Furthermore, this drug only eliminates ~half of senescent cells, not all. If we made some incremental improvements, this could easily give us a 70% increase.
tldr: senolytics are coming soon, and some sort of senolytic is going to give us a 30% lifespan increase, which will buy us time to reach immortality. Show me mechanistically why this study from mice wouldn't translate into humans.
https://www.nih.gov/news-events/nih-research-matters/eliminating-senescent-cells-extends-healthy-life-mice
I have reason to believe this 36% increase in mice will translate into a ~30-40% increase in humans. Firstly, humans have proportionally more senescent cells than mice. Secondly, Since this drug is not a calorie restriction mimetic, it's positive effects will not diminish when given to a larger organism. Furthermore, this drug only eliminates ~half of senescent cells, not all. If we made some incremental improvements, this could easily give us a 70% increase.
tldr: senolytics are coming soon, and some sort of senolytic is going to give us a 30% lifespan increase, which will buy us time to reach immortality. Show me mechanistically why this study from mice wouldn't translate into humans.
