>>12289411the "increase in gene transcription" is limited to a subset of genes and is not indefinite. most mechanisms that cause an increase in transcription involve transcription of something that eventually inhibits or suppresses this transcription. The general term is negative feedback or feedback inhibition, and it's very common. Something typical is a transcription factor that activates transcription of its own inhibitor/suppressor (among other things). Cancer is really a disease of de-regulation - when these regulatory mechanisms are disrupted, that's when you have a problem. Even then, there are mechanisms to avoid these problems. This is one of the reasons cancer is typically a disease of aging. Children with cancer almost always have a genetic factor that facilitated oncogenesis. I could go on. Nice dubs.
