to extend a little bit more effort: not in this context but rather to rail against polyunsaturated fatty acids in our diets, i've seen people suggest that they could be causing malformation of cardiolipin, which could lead to protons leaking across the inner membrane prior to being pumped through complex v of the ETC
so that could be one reason
also, slow metabolism also seems to be caused by eating fewer calories than your body requires, for too long a period of time. which, maybe if you combine that with persistently high insulin, that would result in insufficient inputs to the ETC?
