I know this is quite a longshot considering that this board has very few chemists, let alone experienced chemists. But lets try.
I'm looking for a textbook or other type of material that will teach me some practical tips in organic synthesis: actual real world reactions and reaction conditions, maybe some advanced purification methods, how to generate reactants in situ, how to choose a solvent, how to tell when I will need absolute solvent and when will I need to work under inert atmosphere, etc.
I'm having quite a few problems with my organic synthesis since the department I work at is more physics oriented (magnetism and such). The work here is done mostly with metal complex chemistry where we use maybe 3 reactions 99 % of the time (ketone or aldehyde + amine condensation, N-alkylation and reductive amination).
My current problem is pic releated (it's just a scheme not a real reaction of interest). How do I get the product on the left rather than the one on the right? Can I somehow increase the nuclephilicity of the nitrogens? Water removal with Dean-Stark or other method? I used absolute ethanol and orthoformate to absorb the water from reaction. I also tried catalysis with various acids and high reaction temperatures in ethylenglycole and I still get the imidazole product. Would increasing reaction time help?
I'm looking for a textbook or other type of material that will teach me some practical tips in organic synthesis: actual real world reactions and reaction conditions, maybe some advanced purification methods, how to generate reactants in situ, how to choose a solvent, how to tell when I will need absolute solvent and when will I need to work under inert atmosphere, etc.
I'm having quite a few problems with my organic synthesis since the department I work at is more physics oriented (magnetism and such). The work here is done mostly with metal complex chemistry where we use maybe 3 reactions 99 % of the time (ketone or aldehyde + amine condensation, N-alkylation and reductive amination).
My current problem is pic releated (it's just a scheme not a real reaction of interest). How do I get the product on the left rather than the one on the right? Can I somehow increase the nuclephilicity of the nitrogens? Water removal with Dean-Stark or other method? I used absolute ethanol and orthoformate to absorb the water from reaction. I also tried catalysis with various acids and high reaction temperatures in ethylenglycole and I still get the imidazole product. Would increasing reaction time help?
