>>12098447The challenges in engineering bacterial cells to this end are things such as:
- Ensuring that the bacteria only targets the correct cells. This would require a lot of tuning and protein design for each type of cancer for the cells to only recognize those individual extracellular environments
-Making sure the bacterial cells can actually get to the area of interest with illicitng and immune response in the host.
-Getting the cells to consistently eliminate 100% of cancerous tissue
-Making sure that all the cells are eliminated from the body as soon as their function is completed
- Making the entire system robust to evolutionary changes that could break one of these components
Youre much better off advancing the development of Car-T cells than trying to do the same thing with bacteria
