I'm an undergraduate student and need to give input at our next lab meeting. Our lab head is pretty strict and will be mad if I don't have any input, and I'm afraid I understood it incorrectly.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316504/
It has to do with a Biologic Internal defibrillator, a BioICD is what they call it. They use a simulated Ion channel which responds to high heart frequency and supposedly ends tachy-arrhythmia. The main problem I seem to have with this is they say they have a proof of concept, but everything they do is only simulated through an algorithm. They don't have an actual protein to do the things they want. do they intend to find some kind of ion channel protein that responds to high frequency in the wild? In their program they can raise the "level of protein expression" to increase the sensitively to frequency but how do they intend to do this with a real protein (if they ever find/create it)? What stops the protein from reacting to a normal increase of heart rate just from exercising?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316504/
It has to do with a Biologic Internal defibrillator, a BioICD is what they call it. They use a simulated Ion channel which responds to high heart frequency and supposedly ends tachy-arrhythmia. The main problem I seem to have with this is they say they have a proof of concept, but everything they do is only simulated through an algorithm. They don't have an actual protein to do the things they want. do they intend to find some kind of ion channel protein that responds to high frequency in the wild? In their program they can raise the "level of protein expression" to increase the sensitively to frequency but how do they intend to do this with a real protein (if they ever find/create it)? What stops the protein from reacting to a normal increase of heart rate just from exercising?
