Hi all,
I'm doing my honours thesis, and my project was sortof suggested to me by my supervisor bc of covid. It turns out with the data i'm going to have to do a 2x2x2x2 MANOVA with 7 different dependent variables. Has anyone ever done an excessive MANOVA/ANOVA like this? I've always gotten the impression from my lectures that its bad practise. Also with that many groups theres about 112 fucking interactions. With so many post hoc tests how would i ever get a significant finding with bonferrini's correction?
Research design:
1st IV: Sex
2nd: BDNF HET genetic mutation (or not)
3rd: chronic meth treatment
4th: a final meth challenge before euthanasia
The dependent variables are the counts of immunoreactive neurons in 7 different brain regions.
Hypothesis is whether the mutation will impact 'sensitivity' to meth (opposite of tolerance - occurs when taking meth again after abstinence)
IE Rats treated with chronic meth AND in the challenge dose group should have more IR cell counts than rats treated with chronic saline + challenge meth dose
Also general stats discussion
I'm doing my honours thesis, and my project was sortof suggested to me by my supervisor bc of covid. It turns out with the data i'm going to have to do a 2x2x2x2 MANOVA with 7 different dependent variables. Has anyone ever done an excessive MANOVA/ANOVA like this? I've always gotten the impression from my lectures that its bad practise. Also with that many groups theres about 112 fucking interactions. With so many post hoc tests how would i ever get a significant finding with bonferrini's correction?
Research design:
1st IV: Sex
2nd: BDNF HET genetic mutation (or not)
3rd: chronic meth treatment
4th: a final meth challenge before euthanasia
The dependent variables are the counts of immunoreactive neurons in 7 different brain regions.
Hypothesis is whether the mutation will impact 'sensitivity' to meth (opposite of tolerance - occurs when taking meth again after abstinence)
IE Rats treated with chronic meth AND in the challenge dose group should have more IR cell counts than rats treated with chronic saline + challenge meth dose
Also general stats discussion
