>>11985964Indefinite. The most damage that we suffer is currently:
Iron accumulating and replacing manganese. This turns MnSOD, a protein that protects from oxidative damage into a protein that oxidizes. Also causes obesity, diabetes and brain damage.
Copper deficiency. Causes dementia and iron accumulation. Copper is needed in iron and manganese regulating proteins and manganese is needed in copper regulating proteins, so deficiency in both may sem better than deficiency in one.
Calcium overload, leading to calcification. 300mg is sufficient and Mg seems to be necessary for Ca export from cells. Death from cardiovascular disease in the 60s is usually from this.