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I started taking L-Methyfolate a few years ago as a supplement. It seems to have helped me some. My mood and emotions are more regular. I sleep better (but still poorly). Before I was basically non-functional from bouts of serious depression and terrible sleep that left me falling asleep standing/driving. I subsisted that way for years, but since starting with l-methyfolate have been able to finish a degree. Not sure if just a coincidence.
That being said, though I don't have serious bouts of depression anymore like I used to most of my life, I do sometimes get overcome with anxiety with things are too stressful or overwhelming. Additionally, I am less sensitive to positive emotion, too. Not just negative emotion, but all emotion. I don't get the same deep feeling of empathy or deeply moved experience from music. Sometimes certain songs or shows I went to were nearly transcendental, I now feel cut off from this energy. Additionally, I'm less interested in sex and romance. I rarely feel lonely except when I am extremely stressed.
Did I fry my brain by taking a supplement/medical food to help treat my depression, /sci/? Or am I just getting old? Age 28 if it matters. Been using l-methylfolate for about 3 years. It was a slow, long term, and subtle change.